Simultaneous Prediction Intervals for Dose-response Curve Quality Control

Simultaneous Prediction Intervals for Dose-response Curve Quality Control

Dose-response curves are widely used to assess pharmacological, radiological, or toxicological effects in medical research and clinical applications. A dose-response design can provide evidence of causal effects between exposure/treatment and responses; however, such conclusions heavily rely on the quality of the dose-response curves. Thus there is considerable interest in developing analytical...

Dose–response Curve Prediction Using GPFR Models with Applications to the Control of Renal Anaemia

Construction of a dose – response curve by induction of premature chromosome condensation for biological dosimetry

Premature Chromosome Condensation (PCC) appears to have a possible utility for biological dosimetry purposes. The PCC technique may be adapted for cases of suspicion of overexposure where sampling is performed at least one day after an accident. For this purpose, human blood samples were exposed in vitro to 60Co up to 10 Gy and the PCC technique was performed immediately after irradiation. Anal...

Evaluation of chemosensitivity prediction using quantitative dose–response curve classification for highly advanced/relapsed gastric cancer

BACKGROUND The use of standard chemotherapy regimens has changed the application of chemosensitivity tests from all chemotherapy-eligible patients to those who have failed standard chemotherapy, which includes patients with highly advanced, relapsed, or chemoresistant tumors. METHODS We evaluated a total of 43 advanced primary and relapsed gastric cancers for chemosensitivity based on drug do...

Prediction Intervals for Performance Prediction

The Predictive Performance Equation (PPE) is a mathematical model of learning and forgetting developed to capture performance effectiveness across training histories, and to generate precise, quantitative point predictions of performance by extrapolating the unique mathematical regularities indicative of the learner. This equation is implemented in the Predictive Performance Optimizer (PPO) cog...